The origins of the castle of Poggio Nativo are around the year 1000, the first mention of the castle is in 1055 and its founder was a certain Buonuomo, whose son and heir, Donadeus had given the name to the fortified settlement. Donadeo was a vassal of the counts of Sabina, who became lords of the castle. In 1159 the last descendant, Rainaldo di Sinibaldo, donated Poggio Nativo to Pope Adriano IV. The successive historical events of Poggio Nativo are rather intricate, in the XIV century it underwent a series of complex passages of ownership between the nuns of San Paolo, Andreuccio da Palombara and Farfa, until at the beginning of the 15th century it was occupied by Paolo Savelli, who boasted a substantial credit with the Holy See. In 1460, however, Giacomo Savelli sided against the Pope and supported the Angevins in the dynastic struggle for the Kingdom of Naples against Ferdinand of Aragon. The papal reaction did not wait: Antonio Piccolomini, nephew of the Pope, besieged the castle and took it out. Poggio Nativo was confiscated from the Savelli and then sold to Monsignor Giorgio Cesarini and to the brothers della Valle to pass pious to the capitulation of San Pietro in the Vatican. In 1480 the castle returned to the possession of Cardinal Giovan Battista Savelli, who had it in the Vicariate of Pope Sixtus IV. The Savelli, Bernardino with his wife Lucrezia Anguillara provided for the renovation of the baronial building. In 1625 Urban VIII elevated the land of Poggio Nativo to duchy, in 1633 the castle was sold to Marcantonio Borghese.